Japanese
 NBRP Rat No: 0536 Strain Name: CLX/Ta Commmon Name: Circling behavior linked to the X-chromosome (CLX)
 Principal Investigator  Yuji Iizawa
 Organization   Takeda Chemical Industries, Ltd.  
 Address   2-17-85, jusohonmati, yodogawa-ku

532－8686 Osaka

  Japan
 Telephone  06-6300-6868  Fax:  06-6300-6207  Izawa_yuji@takeda.co.jp
 Inbred Generations   F38 (Mar 2008)  
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  "USER" shall not utilize "THE RESOUCE (ExHC/Ta)" for research The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
aimed at discovering or validating drug candidates.
 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin A male rat showing circling behavior was found among the Jcl:Wistar rats at Takeda Chemical Industries, Ltd. in 1993 (Fuji, 2002). (May 28, 2010) 
 Strain Characteristics Circling behavior phenotype is controlled by a single sex-linked recessive gene <i>clx</i> (circling behavior linked to X chromosome) (Fuji, 2002). The main behavioral features of the abnormal behavior rats are intermittent circling and head tossing with the neck twisted. CLX rats showed no nystagmus after rotating stimulation and the result of air righting reflex test and negative geotaxis test suggested that CLX rats may have some defect in vestibular function (Fuji, 2003). CLX rats showed hyperactivity in the open field test. (May 28, 2010) 
 Breeding Conditions Maintained by crossing sib mating between <i>clx</i>/Y males and <i>clx</i>/<i>clx</i> females. The circling behavior is not seem to influence the reproductive ability (Fuji, 2002). (May 28, 2010) 
 Genotyping  
 References  Fuji J, Fukuda R, Imoto F, Ooshima Y.
New behavioral mutant rat exhibiting circling behavior (clx) controlled by a sex-linked recessive gene.
Congenit Anom (Kyoto). 42(3):187-93, 2002.

Fuji J, Tanabe H, Fukuda R, Ooshima Y.
Defective balancing ability and hyperactivity in the CLX (circling behavior linked to the X-chromosome) mutant rat.
Congenit Anom (Kyoto). 43(4):294-301, 2003.