Japanese
 NBRP Rat No: 0557 Strain Name: LE.AR-EdnrbSl/Okkm Commmon Name: LE.AR-sl
 Principal Investigator  Tohru Kimura
 Organization   National Institute for Physiological Sciences Center for Experimental Animals
 Address  38 Nishigo-naka, Myodaiji, Okazaki

444-8585  Aichi

  Japan
 Telephone  0564-55-7882  Fax:  0564-55-7881  kimura@nips.ac.jp
 Inbred Generations   F10 (May 2008) 
   
 Coat Color
 Deposition Status
 
 black hooded
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Ednrb: endothelin receptor type B
 Origin AR rats (NBRP No.0556) were found a by Ikadai <i>et al.</i> at Institute for Animal Reproduction in 1973 (Ikadai, 1979). From 1997, backcross of AR rats onto Long Evans rats has started. After the 9th generation of backcrossing, it has been maintained by sib mating (F10 in May 2008). (Jul 7, 2009) 
 Strain Characteristics This congenic strain is characterized by megacolon and white coat color with a small pigmented spot on the head as shown in AR rat (Ikadai, 1979). This congenic strain usually dies within 1-5 weeks of age, but some individuals can survive, which suggest that a Long Evans gene might rescue their phenotype. (Jul 7, 2009) 
 Breeding Conditions Homozygous <i>sl</i> rats die within 1-5 weeks of age. The <i>sl</i> mutation is maintained in heterozygous condition (closed colony). (Jul 7, 2009) 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Ednrb_sl_en.pdf">Genotyping protocol for Ednrb</a> 
 References