Japanese
NBRP Rat No: 0559
Strain Name
:
F344-Chr 3
SDT
/Nyo
Commmon Name: F344.SDT-chr3 consomic
Principal Investigator
Susumu Seino
Organization
Kobe University Graduate School of Medicine
Address
7-5-1 Kusunoki-cho, Chuou-Ku, Kobe
650-0017 Hyogo
Japan
Telephone
078-382-5364
Fax: 078-382-5379
seino@med.kobe-u.ac.jp, yokoi@med.kobe-u.ac.jp
Inbred Generations
N8F2 (Jul 2008)
Coat Color
Deposition Status
albino (c)
Embryo
Sperm
Live Animals
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The recipients shall cite the references of the resource and acknowledge the depositor as the source of the resource in the publications. Depending on the project of the recipients, a collaborative arrangement with the depositor could be required. In this case, the recipients shall discuss with the depositor.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Origin
This consomic strain carries Chromosome 3 of SDT/Jcl on F344/NSlc background. (May 31, 2010)
Strain Characteristics
This rat shows inflammation and fibrosis in and around the pancreatic islets but does not develop diabetes. Transferred Chromosome 3 from SDT/Jcl contains QTL <i>Dmsdt1</i>, which associates with inflammation and fibrosis in and around the pancreatic islets of SDT/Jcl (Fuse, 2008). (May 31, 2010)
Breeding Conditions
Sib mating.
Genotyping
References
Fuse M, Yokoi N, Shinohara M, Masuyama T, Kitazawa R, Kitazawa S, Seino S:
Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat.
Physiol Genomics. 2008 Sep 17;35(1):96-105.