Japanese
 NBRP Rat No: 0560 Strain Name: KFRS2/Kyo Commmon Name: SRR02
 Principal Investigator  Takashi Kuramoto
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  Japan
 Telephone  075-753-4494  Fax:  075-753-4409  kuramot@anim.med.kyoto-u.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 siamese (sia)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Tyr: tyrosinase
 Origin One male rat "SRR-Do Your Best" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Do Your Best" and a female PVG/Seac. (Sep 25, 2009) 
 Strain Characteristics This strain has siamese mutation (<i>sia</i>) which causes pigmentation on the edge of the nose, hip and ear, as in the Siamese cat or for the satin mutation (<i>sat</i>) which causes rough fur. <i>sia</i> and <i>sat</i> were mapped to rat chromosome 1 and 3, respectively. Candidate gene analysis revealed that a missense mutation in exon 1 of the tyrosinase gene, S79P, was responsible for <i>sia</i> (Kuramoto, 2010). (May 24, 2010) 
 Breeding Conditions Maintained by crossing of homozygous and satin heterozygous. Poor breeding performance. Young females and old males are suitable for breeding. Id est, we start smear test at 7 weeks of age and cross females with their father (parent-offspring mating). (Sep 25, 2009) 
 Genotyping  
 References  Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Genetic analyses of fancy rat-derived mutations.
Exp Anim. 2010;59(2):147-55.