Japanese
 NBRP Rat No: 0633 Strain Name: W.GR-Ugt1a1j/Aon Commmon Name: WGR
 Principal Investigator   Sachiko Aono
 Organization   Aichi Human Service Center Department of Perinatology, Institute for Developmental Research
 Address  713-8 Kagiyacho, Kasugai

480-0392 Aichi

  JAPAN
 Telephone  0568-88-0811  Fax:  0568-88-0829  saono@inst-hsc.jp
 Inbred Generations   SDGR：F73、WGR：F22 
   
 Coat Color
 Deposition Status
 
 白
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Ugt1a1: UDP glucuronosyltransferase 1 family, polypeptide A1
 Origin After SDGR rats were backcrossed with Wistar rats ten times, This strains were established.
 
 Strain Characteristics WGR strains having a 1 base deletion in Ugt1a1 show hyperbilirubinemia. WGR are better reproductive peformance than SDGR.
 
 Breeding Conditions  
 Genotyping  
 References  Sato, H., Aono, S., Kashiwamata, S. and Koiwai, O. (1991) Genetic defect of bilirubin UDP-glucuronosyltransferase in the　hyperbilirubinemic Gunn rat. Biochem. Biophys. Res. Commujn., 177, 1161-1164.

Keino, H., Sato, H., Semba, R., Aono, S., Aoki, E., and Kashiwamata, S. (1985-86) Mode of prevention by phototherapy of cerebellar hypoplasia in a new Sprague-Dawley strain of jaundiced Gunn rats. Peidat. Neurosci., 12, 145-150.