Japanese
 NBRP Rat No: 0631 Strain Name: DRU/Uubc Commmon Name: 
 Principal Investigator  Hideyuki Tanaka
 Organization    Faculty of Agriculture, Utsunomiya University Department of Applied Biochemistry
 Address  

321-8505 Utsunomiya

 Japan
 Telephone  028-649-5464  Fax:  028-649-5401  tanakah@cc.utsunomiya-u.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin The mutant rat showing microphthalmia was found in the colony of Donryu rats at Central Institute for Experimental Animals in 1974. A pair of F3 rats was transferred to The Third Department for Anatomy, School of Medicine, Chiba University in 1975 and maintained by sib mating. F50 rats were transferred to Faculty of Agriculture, Utsunomiya University by Dr. S Sugita in 1991. (Nov 25, 2010) 
 Strain Characteristics Hereditary microphthalmic rat. Eye-ball is not seen through the eye-fissure of DRU rats. DRU rats lack the optic nerve completely due to growth inhibition of the inner layer of the optic cup at the early embryonic stage (Kobayashi, 1981). Marked decreases in volumes and the number of neurons of lateral geniculate nucleus (LGN) has been reported (Sugita, 1983). The thickness of some layers of striate cortex is decreased (Sugita, 1984), and the neuronal population and volume of the suprachiasmatic nucleus (SCN) are smaller than those of control rats (Sugita, 1992). These mutant phenotypes are hereditary but the causative gene(s) have not been identified. (Nov 25, 2010) 
 Breeding Conditions Sib mating. 
 Genotyping  
 References  Kobayashi K, Otani K.
Morphogenesis of the hereditary microphthalmia in a new strain of rat.
J Morphol. 1981 Mar;167(3):265-76.

Sugita S, Otani K.
Quantitative analysis of the lateral geniculate nucleus in the mutant microphthalmic rat.
Exp Neurol. 1983 Nov;82(2):413-23.

Sugita S, Otani K.
Quantitative analysis of the striate cortex in the mutant microphthalmic rat.
Exp Neurol. 1984 Sep;85(3):584-96.

Sugita S, Ohsawa K.
[Morphometric and immunohistochemical studies of the suprachiasmatic nucleus in the hereditary microphthalmic rat]
Jikken Dobutsu. 1992 Oct;41(4):437-42.