We are developing genome humanization technologies using genome editing to elucidate the molecular basis of human diseases and accelerate the development of novel therapies. Our research focuses on large-scale replacement of genomic regions with their human counterparts and the generation of humanized animal models, with the goal of establishing next-generation experimental models for biomedical research.
We are developing next-generation genome engineering technologies based on the CRISPR-Cas3 system, with applications ranging from basic research to medicine and biotechnology. By integrating epigenome editing and genome imaging with CRISPR-based platforms, we aim to establish versatile multi-genome engineering technologies that will provide a foundation for next-generation biomedical research and precision medicine.
We investigate the molecular mechanisms underlying host–microbe and host–virus interactions using genome editing technologies and humanized animal models. Our research focuses on developing strategies to eliminate DNA viruses such as hepatitis B virus (HBV), establishing gut microbiota-mimicking animal models, and creating CRISPR-based diagnostic technologies for infectious diseases, with the goal of building next-generation research infrastructure for infectious disease research.
Our laboratory is dedicated to the development of genetically modified rat models using genome editing technologies and the expansion of rat bioresources. Through international collaborations centered on the National BioResource Project for the Rat (NBRP-Rat), we are promoting the development of research databases and AI-driven gene function analysis to establish next-generation infrastructure for rat research.
7/10、NTU Singapore(シンガポール)動物実験施設長のTamara Ramadan先生が来訪されました。動物施設見学と共に、施設運営について貴重な意見交換をさせていただきました🇸🇬🇯🇵Thanks! pic.twitter.com/bcWsEnk5rp
— 京大医_吉見一人研究室（Yoshimi Kazuto Lab, Kyoto Univ. Med） (@YoshimiLab_KU) July 11, 2026
